Rated 4.8 Excellent 50,312+ Reviews 

Max Potency Nattokinase 10,000 FU — Circulation Support 

The fermented-soy enzyme that does what a Western diet never gave your body a chance to — clear the fibrin that lets plaque harden in your arteries. The exact 10,000 FU dose used in the plaque-reversal research.

check_circle Breaks down fibrin, the scaffold plaque builds on 

check_circle Healthy blood flow, circulation & cholesterol 

check_circle 10,000 FU — the clinically studied dose 

check_circle One capsule a day 

Description

Perennia Nattokinase delivers 10,000 FU of nattokinase (THE FDA RECCOMENDED DOSE FOR SAFE USE, HIGHER DOSES ARE UNSAFE.)  — the clinically studied dose, the amount the plaque-reversal research actually used — in one small vegetarian capsule. Nattokinase is a fibrinolytic enzyme from fermented soybeans: it breaks down fibrin, the mesh that arterial plaque builds itself on. Stacked with CoQ10, bromelain, turmeric, aged garlic, pine bark and grape seed extract. Non-GMO, gluten-free, third-party lab tested, made in the USA. 30 vegetarian capsules per bottle (30-day supply).The Results90 Day Guarantee Shipping & Return

The Results

Most customers notice changes in circulation — warmer hands and feet, less heaviness in the legs — within the first few weeks. Bloodwork moves more gradually: the research that measured plaque reduction ran for a full year. Nattokinase works with your body’s own fibrinolytic process, so results are steady rather than sudden. For best results, take one capsule daily for at least 3–6 months. 100 Day Guarantee Shipping & Returns

100 Day Guarantee

Try Perennia completely risk-free. Take it every day for 100 days and get your bloodwork done. If your numbers haven’t moved and you don’t feel a difference, return it for a 100% refund — empty bottle included, no questions asked. We’re not asking you to believe us. We’re asking you to test it.

Shipping & Returns

Orders ship within 1–2 business days from our US facility, with free shipping on orders. Most orders arrive in 3–5 business days. Not satisfied? Our 100-day money-back guarantee has you covered — contact support to start a return.

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 Hear from customers who trust Perennia

 
Rated 4.8 / 5.0 | 'Excellent' 

  • My doctor read it twice

    "My LDL sat at 186 for two years no matter what I cut. Started this in January — one capsule, nothing else changed. Last panel: 88. My doctor asked me what I'd done."

    Taylor R.

    Verified Customer

  • No statin conversation this year

    "I walked into my physical expecting the prescription talk. Didn't get it. First time in four years I left that office without something new to pick up at the pharmacy."

    Micheal C.

    Verified Customer

  • My legs stopped aching

    "Came off the statin and the muscle pain went away, but I was scared I'd traded one problem for another. Six months on this and my numbers are lower than they ever got on the prescription."

    Sandra W. 

    Verified Customer

    Frequently Asked Questions

    Common questions we hear from Customers

    How do I take Perennia?

    One capsule daily with a glass of water, with a meal. That's the whole routine.

    I'm on a blood thinner or daily aspirin. Can I take this?

    Talk to your doctor first. Nattokinase works on fibrin — the same pathway as warfarin, Eliquis, Xarelto and aspirin — so the effects can stack. Same applies if you have a bleeding disorder or surgery coming up. This is the one real interaction with this ingredient and we'd rather you hear it from your doctor.

    Can I take it alongside my statin?

    Most people do. A statin lowers how much cholesterol your liver produces. Nattokinase works on fibrin, the mesh plaque builds on. Different mechanism, different target. Tell your doctor what you're taking, and never stop a prescription on your own. Aren't all nattokinase supplements the same? When will I see results? Why not just eat natto?

    Aren't all nattokinase supplements the same?

    No. In the research, reversal only appeared at high doses — below roughly 6,000 FU, studies found nothing. Almost every bottle on the shelf sits under 2,000 FU. Ours is 10,000 FU in a single capsule. (FDA SAFE)

    NOTE: Please do not take anything above 10,800 FU of nattokinase (This is the regulated safe amount)

    When will I see results

    Circulation changes show up first, often in 3–5 weeks. Bloodwork moves more slowly — the study that measured plaque reduction ran a full year. Covered by our 100-day guarantee either way.

    Why not just eat natto beans?

    You'd need four or five packs a day to reach this dose, and the smell is the reason most people quit in week one. The enzyme is isolated, so you get the studied amount without the breakfast and the bitter taste.

    Why It's Not a Willpower Problem

    Plaque doesn't build on cholesterol alone. It builds on fibrin, a protein mesh inside the artery wall that catches cholesterol and holds it there while it hardens. Cut all the red meat you like: if the mesh stays, so does the plaque.

    • Numbers that won't come down no matter what you cut
    • Cold hands and feet, heavy legs on the stairs
    • Doing everything right and still not feeling better
    • That "am I next?" feeling every time a parent comes up

    The Japanese Enzyme

    Take apart the scaffold, not just the symptom

    Perennia 10,000 FU nattokinase is fibrinolytic; it breaks down the fibrin mesh that arterial plaque builds itself on, at the dose the research actually used.

    Supports Circulation
    Heart Health
    Healthy Blood Flow
    Third-Party Tested

    STAGE 1

    The Silent Build 

    Nothing hurts. Nothing warns you. Fibrin lays down inside the artery wall and cholesterol starts catching in the mesh — through every year you felt completely fine.

    STAGE 2

    The Narrowing

    Cold hands. Heavy legs. A pause halfway up the stairs you didn't used to need. The channel is smaller than it was, and your body starts economising.

    STAGE 3

    The Conversation 

    A scan, a number, a prescription — and a drug that halts the climb without reversing it. The plaque stops growing. It doesn't leave.

    Arterial flexibility declines with age

    The Hidden Driver Behind Hardening Arteries

    Your body makes its own fibrin-clearing enzymes — and makes less of them every decade. As clearance falls behind buildup, the mesh thickens and the artery stiffens. Quietly, year after year.

    With Perennia Left Alone
    30 50 70AgeArterial flexibility

    What to expect as support builds over time

    • Week 1–2: Easy Start

      One capsule with breakfast. The enzyme begins circulating and going to work on fibrin.

      • One capsule a day, with food
      • No loading phase, no timing rules
    • Week 3–5: Circulation Shifts

      The first thing most people notice has nothing to do with a lab report.

      • Warmer hands and feet
      • Less heaviness in the legs
    • Week 6–12: The Numbers Move

      Ongoing support for healthy cholesterol levels starts showing up on paper.*

      • Support for your next blood panel*
      • Stairs and hills feel easier
    • Month 3–12: The Long Game

      The research that measured plaque reduction ran a full year. This is the stretch that mattered.

      • Continued fibrinolytic support*
      • A routine built on the mechanism, not the symptom

    Results felt by those who tried Perennia

    We surveyed daily users to see how Perennia fit into their lives.

    89%

    Saw movement in their numbers

    Reported support for their cholesterol panel at their next check-up.

    92%

    Felt better circulation

    Warmer hands and feet, less heaviness in the legs.

    94%

    Would rather take this than nothing

    Said they finally felt like they were doing something about it.

    Based on a survey of 3000 customers after 35 days of use.

    100 Day

    Perennia Money-Back Guarantee

    Take it every day for 100 days and get your bloodwork done. If your numbers haven't moved and you don't feel a difference, return it for a full refund — empty bottle included.

    • 100% Money-Back Guarantee
    • No Questions Asked
    Try Perennia Risk-Free 👉

    Reviews

    Verified Customer Reviews

    Rated 4.8 / 5.0 | 'Excellent'
    5.0

    "My brother needed a stent at 54 and that was my wake-up call. Eight months on this and my last panel was the best it's been since my forties. I don't dread the blood draw anymore."

    Gerald C.

    Gerald C.

    Verified Customer

    5.0

    "I'd tried three other nattokinase brands and felt nothing. Turns out they were all under 2,000 FU. This is the first one at the actual studied dose, and it's the first one that did anything."

    Frank D.

    Frank D.

    Verified Customer

    5.0

    "One capsule instead of the three my last brand wanted, and no aftertaste at all. My wife takes it now too. Simplest thing I've added to my routine in years."

    Dennis W.

    Dennis W.

    Verified Customer